Clearing the JUNQ: the molecular machinery for sequestration, localization, and degradation of the JUNQ compartment
Cellular protein homeostasis (proteostasis) plays an essential role in regulating the folding, sequestration, and turnover of misfolded proteins via a network of chaperones and clearance factors.Previous work has shown that misfolded proteins tinted balm are spatially sequestered into membrane-less compartments in the cell as part of the proteostas